Author: Andrabi, Raiees; Pallesen, Jesper; Allen, Joel D.; Song, Ge; Zhang, Jinsong; de Val, Natalia; Gegg, Gavin; Porter, Katelyn; Su, Ching-Yao; Pauthner, Matthias; Newman, Amanda; Bouton-Verville, Hilary; Garces, Fernando; Wilson, Ian A.; Crispin, Max; Hahn, Beatrice H.; Haynes, Barton F.; Verkoczy, Laurent; Ward, Andrew B.; Burton, Dennis R.
Title: The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template Document date: 2019_5_21
ID: 1ni7949q_16
Snippet: Proximal to the viral membrane is the gp41 subunit that forms the base of the trimer spike and is arranged into heptad repeat-1 (HR1), HR2, and the fusion peptide (FP) ( Figure 2B ). Similar to the HIV Env trimer, the three C-terminal helices of HR1 are centrally positioned along the trimer axis perpendicular to the viral membrane (Julien et al., 2013a; Lyumkis et al., 2013; Pancera et al., 2014) . Intriguingly, the FP region, which has been obse.....
Document: Proximal to the viral membrane is the gp41 subunit that forms the base of the trimer spike and is arranged into heptad repeat-1 (HR1), HR2, and the fusion peptide (FP) ( Figure 2B ). Similar to the HIV Env trimer, the three C-terminal helices of HR1 are centrally positioned along the trimer axis perpendicular to the viral membrane (Julien et al., 2013a; Lyumkis et al., 2013; Pancera et al., 2014) . Intriguingly, the FP region, which has been observed to be solvent exposed on the outside of the HIV Env, is positioned in a pocket inside the MT145K trimer and remains sequestered in all three protomers ( Figure 2E ).
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