Author: Hoffmann, Markus; González Hernández, Mariana; Berger, Elisabeth; Marzi, Andrea; Pöhlmann, Stefan
Title: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent Document date: 2016_2_22
ID: 146cwh6y_37
Snippet: In sum, the present study suggests that filoviruses do not need to adapt their entry mechanism to successfully jump between bats, NHPs and humans. However, differences in the efficiency with which filovirus species infect certain reservoir hosts might exist and might be due to polymorphisms in NPC1 [73] and/or additional host cell factors......
Document: In sum, the present study suggests that filoviruses do not need to adapt their entry mechanism to successfully jump between bats, NHPs and humans. However, differences in the efficiency with which filovirus species infect certain reservoir hosts might exist and might be due to polymorphisms in NPC1 [73] and/or additional host cell factors.
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