Author: Hoffmann, Markus; Krüger, Nadine; Zmora, Pawel; Wrensch, Florian; Herrler, Georg; Pöhlmann, Stefan
Title: The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells Document date: 2016_3_30
ID: 0ejhd9nw_38
Snippet: Of note, during the preparation of this manuscript, Maruyama and colleagues published a manuscript reporting batFLUAV-HAL-driven entry into bat cell lines different from those used in the present study (Maruyama et al., 2015, doi: 10 .1016/j.virol.2015.11.002.). Both studies show that HAL-driven entry requires prior proteolytic HAL-activation by trypsin and endosomal acidification but is independent of sialic acids. The present work extends these.....
Document: Of note, during the preparation of this manuscript, Maruyama and colleagues published a manuscript reporting batFLUAV-HAL-driven entry into bat cell lines different from those used in the present study (Maruyama et al., 2015, doi: 10 .1016/j.virol.2015.11.002.). Both studies show that HAL-driven entry requires prior proteolytic HAL-activation by trypsin and endosomal acidification but is independent of sialic acids. The present work extends these findings by demonstrating that HAL can utilize the human enzyme TMPRSS2 for its activation.
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