Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_21
Snippet: Replacing GGG with GGA, the most common variant found in natural isolates, disrupts the lower stem structure and this change decreased frameshift efficiency to 7.8% (P < 0.001), indicating that disrupting the base of the stem weakens frameshifting to a minor degree. Efficiency was also somewhat reduced when the GGG codon was maintained but the lower stem was disrupted by substituting the natural UU with AA nucleotides on the opposing strand of th.....
Document: Replacing GGG with GGA, the most common variant found in natural isolates, disrupts the lower stem structure and this change decreased frameshift efficiency to 7.8% (P < 0.001), indicating that disrupting the base of the stem weakens frameshifting to a minor degree. Efficiency was also somewhat reduced when the GGG codon was maintained but the lower stem was disrupted by substituting the natural UU with AA nucleotides on the opposing strand of the stem (GGG_AA).
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