Author: Grabiec, Aleksander M.; Hussell, Tracy
Title: The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation Document date: 2016_3_8
ID: 1f47gvys_28
Snippet: Finally, while previous studies have solely focused on efferocytosis by airway macrophages, mounting evidence suggests that bronchial epithelial cells might be equally important in clearing apoptotic cells from the inflamed airways. Even though epithelial cells are not professional phagocytes, they efficiently engulf apoptotic eosinophils, but not neutrophils [94, 106] . Animal studies demonstrate a critical role for airway epithelial cells in th.....
Document: Finally, while previous studies have solely focused on efferocytosis by airway macrophages, mounting evidence suggests that bronchial epithelial cells might be equally important in clearing apoptotic cells from the inflamed airways. Even though epithelial cells are not professional phagocytes, they efficiently engulf apoptotic eosinophils, but not neutrophils [94, 106] . Animal studies demonstrate a critical role for airway epithelial cells in the removal of apoptotic cells from the inflamed lung and, as a consequence, control of inflammatory responses in the murine model of allergic airway hyper-responsiveness [68] . Future studies in humans are therefore necessary to characterise the relative contributions of airway macrophages and bronchial epithelial cells to defects in apoptotic cell removal in asthma and to identify therapeutic strategies which could restore and/or promote the efferocytic function of both cell types, as well as activate anti-inflammatory transcriptional programmes associated with apoptotic cell recognition.
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