Author: Tan, Jinzhi; Vonrhein, Clemens; Smart, Oliver S.; Bricogne, Gerard; Bollati, Michela; Kusov, Yuri; Hansen, Guido; Mesters, Jeroen R.; Schmidt, Christian L.; Hilgenfeld, Rolf
Title: The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes Document date: 2009_5_15
ID: 1aqt65cc_16
Snippet: The function of the coronaviral X-domain is still unclear; for some coronaviruses such as HCoV 229E and SARS-CoV, it has been shown to exhibit a low ADP-ribose-10-phosphate phosphatase (Appr-10-pase, occasionally also called ''ADRP'') activity and to bind the product of the reaction, ADP-ribose [21] [22] [23] 30] . However, the two subdomains of SUD core do not bind ADPribose, as we have demonstrated by zone-interference gel electrophoresis ( Fig.....
Document: The function of the coronaviral X-domain is still unclear; for some coronaviruses such as HCoV 229E and SARS-CoV, it has been shown to exhibit a low ADP-ribose-10-phosphate phosphatase (Appr-10-pase, occasionally also called ''ADRP'') activity and to bind the product of the reaction, ADP-ribose [21] [22] [23] 30] . However, the two subdomains of SUD core do not bind ADPribose, as we have demonstrated by zone-interference gel electrophoresis ( Figure S1 ).
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