Selected article for: "antigen presentation and immune presentation"
Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
  • Document date: 2009_6_8
    • ID: 19noki6p_5
    Snippet: The migration of DCs from peripheral tissues to lymph nodes is essential for antigen presentation and triggering of adaptive immune responses. The trafficking of DCs is regulated by chemokines in their microenvironment and their expression of chemokine receptors (CCRs). Differential expressions of CCRs are observed during DC maturation [13, 14] and some viruses, such as herpes simplex virus (HSV), can block CCR expressions on DCs to alter their m.....
    Document: The migration of DCs from peripheral tissues to lymph nodes is essential for antigen presentation and triggering of adaptive immune responses. The trafficking of DCs is regulated by chemokines in their microenvironment and their expression of chemokine receptors (CCRs). Differential expressions of CCRs are observed during DC maturation [13, 14] and some viruses, such as herpes simplex virus (HSV), can block CCR expressions on DCs to alter their migratory properties [15] . There are redundancies in the chemokines and CCRs interactions as many different ligands bind the same receptor and many receptors bind the same ligand. For example, RANTES binds to CCR-1, CCR-3 and CCR-5, while MIP-1α also binds to CCR-1 and CCR-5 [16] . We determined if the expression of these receptors on DCs are altered by SARS-CoV and contribute to autocrine regulation of DC migration.

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