Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_2
Snippet: Lassa virus (LASV) belongs to the Arenaviridae, a fast-growing family of rodent-borne viruses, currently including 22 enveloped viruses with bi-segmented, ambisense single-stranded RNA genomes divided into two groups [7] , [8] . The Old World (OW) group contains the prototypic lymphocytic choriomeningitis virus (LCMV) which can cause neuropathology in adults, fetal abnormalities in newborns, and a fatal LF-like disease in immunocompromised patien.....
Document: Lassa virus (LASV) belongs to the Arenaviridae, a fast-growing family of rodent-borne viruses, currently including 22 enveloped viruses with bi-segmented, ambisense single-stranded RNA genomes divided into two groups [7] , [8] . The Old World (OW) group contains the prototypic lymphocytic choriomeningitis virus (LCMV) which can cause neuropathology in adults, fetal abnormalities in newborns, and a fatal LF-like disease in immunocompromised patients. OW viruses also include LASV; and non-pathogenic viruses, Mopeia (MOPV), Mobala (MOBV), and Ippy (IPPYV), as well as newly-found LuJo (pathogenic) [9] and Luna (unknown pathogenicity) [10] viruses. The New World group includes JunÃn, Machupo, Guanarito, Sabia, and Chapare viruses associated with severe VHF in South America [11] .
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