Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_33
Snippet: A total of 122 genes were identified as being differentially expressed at tested time-points ( Figure 1 and Table S1 ). Gene expression changes in ML29 and LASV-exposed PBMC were detected at 4 and 8 hpe respectively, with all genes up-regulated in LASV in contrast to ML29 with 11 down-regulated genes (4 at 4 hpe and 7 at 8 hpe). At 24 hpe LASV-treated PBMC showed the maximum changes (122 genes) in comparison with ML29exposed samples......
Document: A total of 122 genes were identified as being differentially expressed at tested time-points ( Figure 1 and Table S1 ). Gene expression changes in ML29 and LASV-exposed PBMC were detected at 4 and 8 hpe respectively, with all genes up-regulated in LASV in contrast to ML29 with 11 down-regulated genes (4 at 4 hpe and 7 at 8 hpe). At 24 hpe LASV-treated PBMC showed the maximum changes (122 genes) in comparison with ML29exposed samples.
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