Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_39
Snippet: Two other apoptosis-related genes, SPP1 and INHBA, were upregulated 14-and 20-fold, respectively (Table 2) . SPP1, a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein 1 (previous names: osteopontin, bone sialoprotein I), enhances IFNc and IL-12 production and contributes to host defense, bone formation, and wound healing by stimulating macrophage migration as well as protecting against viral and bacterial infections through its .....
Document: Two other apoptosis-related genes, SPP1 and INHBA, were upregulated 14-and 20-fold, respectively (Table 2) . SPP1, a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein 1 (previous names: osteopontin, bone sialoprotein I), enhances IFNc and IL-12 production and contributes to host defense, bone formation, and wound healing by stimulating macrophage migration as well as protecting against viral and bacterial infections through its pro-Th1 effect [54] . Inhibin-beta A (INHBA) joins Inhibin-alpha to form a pituitary follicle-stimulating hormone (FSH) secretion inhibitor. Inhibin has been shown to negatively-regulate gonadal stromal cell proliferation and to have tumor-suppressor activity. INHBA is also up-regulated by vaccinia and inhibits a diverse array of cytokines by enabling vaccinia virus E3 protein to antagonize several distinct but interlinked signaling cascades [55] .
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