Author: Ratul Chowdhury; Costas D Maranas
Title: Biophysical characterization of the SARS-CoV2 spike protein binding with the ACE2 receptor explains increased COVID-19 pathogenesis Document date: 2020_3_31
ID: lotyldfd_10
Snippet: has only one tyrosine (among 16 residues). We have not explored the phylogenetic basis for the presence of tyrosines but they do seem to be important for conferring high binding affinity between SARS-CoV-2 and ACE2 as alluded to by the alanine scan (see Figure 2 ). In contrast, the tyrosines in SARS-CoV-1 (Tyr442, Tyr475, and Tyr491) are mostly idle. We use Figure 3 to explain two representative cases of interface tyrosines from both SARS-CoV-2 (.....
Document: has only one tyrosine (among 16 residues). We have not explored the phylogenetic basis for the presence of tyrosines but they do seem to be important for conferring high binding affinity between SARS-CoV-2 and ACE2 as alluded to by the alanine scan (see Figure 2 ). In contrast, the tyrosines in SARS-CoV-1 (Tyr442, Tyr475, and Tyr491) are mostly idle. We use Figure 3 to explain two representative cases of interface tyrosines from both SARS-CoV-2 (Tyr473 and Tyr489) and SARS-CoV-1 (Tyr442 and Tyr475) RBDs.
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