Author: Ha, Cam T.; Wu, Julie A.; Irmak, Ster; Lisboa, Felipe A.; Dizon, Anne M.; Warren, James W.; Ergun, Suleyman; Dveksler, Gabriela S.
Title: Human Pregnancy Specific Beta-1-Glycoprotein 1 (PSG1) Has a Potential Role in Placental Vascular Morphogenesis Document date: 2010_7_1
ID: k2vbgqk7_34
Snippet: We have previously reported that recombinant GST-PSG1 purified from insect cells induces TGFB1 in human monocytes and in murine macrophages [9] . Human monocytes secreted PSG1 AND ANGIOGENESIS 29 TGFB1 in response to PSG1-Fc treatment, starting at a concentration of 10 lg/ml and up to the highest concentration tested (50 lg/ml) compared to FLAG-Fc-treated cells ( Fig. 2A) . We also observed a significant induction of TGFB1 in human monocytes (be.....
Document: We have previously reported that recombinant GST-PSG1 purified from insect cells induces TGFB1 in human monocytes and in murine macrophages [9] . Human monocytes secreted PSG1 AND ANGIOGENESIS 29 TGFB1 in response to PSG1-Fc treatment, starting at a concentration of 10 lg/ml and up to the highest concentration tested (50 lg/ml) compared to FLAG-Fc-treated cells ( Fig. 2A) . We also observed a significant induction of TGFB1 in human monocytes (between two-and threefold the amount of TGFB1 secreted over the control protein-treated cells, depending on the donor) at a PSG1-FLAG concentration of 10 lg/ml.
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