Author: Zhang, Chunsun; Xing, Da
Title: Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends Document date: 2007_6_18
ID: j0bazhy2_14
Snippet: For serpentine channel continuous-flow PCR chips, parallelization is not easily realized as it complicates the chip architecture and most likely increases the chip footprint. In addition, the number of thermal cycles is usually not adjustable. Importantly, in these PCR chips the temperature zones are linearly arranged and are easy to establish a smooth temperature gradient. In this case, however, a melted single-stranded DNA sample is very likely.....
Document: For serpentine channel continuous-flow PCR chips, parallelization is not easily realized as it complicates the chip architecture and most likely increases the chip footprint. In addition, the number of thermal cycles is usually not adjustable. Importantly, in these PCR chips the temperature zones are linearly arranged and are easy to establish a smooth temperature gradient. In this case, however, a melted single-stranded DNA sample is very likely to form double strands with the template strands or their complementary fragments when passing the extension zone, which compromises the PCR efficiency.
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