Author: Hernandez, Nicholas; Melki, Isabelle; Jing, Huie; Habib, Tanwir; Huang, Susie S.Y.; Danielson, Jeffrey; Kula, Tomasz; Drutman, Scott; Belkaya, Serkan; Rattina, Vimel; Lorenzo-Diaz, Lazaro; Boulai, Anais; Rose, Yoann; Kitabayashi, Naoki; Rodero, Mathieu P.; Dumaine, Cecile; Blanche, Stéphane; Lebras, Marie-Noëlle; Leung, Man Chun; Mathew, Lisa Sara; Boisson, Bertrand; Zhang, Shen-Ying; Boisson-Dupuis, Stephanie; Giliani, Silvia; Chaussabel, Damien; Notarangelo, Luigi D.; Elledge, Stephen J.; Ciancanelli, Michael J.; Abel, Laurent; Zhang, Qian; Marr, Nico; Crow, Yanick J.; Su, Helen C.; Casanova, Jean-Laurent
Title: Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency Document date: 2018_10_1
ID: jqv0lyfx_26
Snippet: She experienced five episodes of bronchiolitis revealing severe asthma (for which she was prescribed montelukast, albuterol, and ipratropium bromide), gingivostomatitis and adenitis, and four episodes of prolonged gastroenteritis. She was hospitalized in the pediatric ICU (PICU) due to idiopathic biliary perforation 14 d after MMR vaccination at 16 mo old; disseminated intravascular coagulation was suspected secondary to thrombopenia (27,000/mm 3.....
Document: She experienced five episodes of bronchiolitis revealing severe asthma (for which she was prescribed montelukast, albuterol, and ipratropium bromide), gingivostomatitis and adenitis, and four episodes of prolonged gastroenteritis. She was hospitalized in the pediatric ICU (PICU) due to idiopathic biliary perforation 14 d after MMR vaccination at 16 mo old; disseminated intravascular coagulation was suspected secondary to thrombopenia (27,000/mm 3 ) and low prothrombin time (40%), associated with elevated liver enzymes (SGOT 274 UI/l and SGPT 128 UI/l). She was readmitted to the PICU 2 mo later with a suspicion of septic shock in the absence of a detectable pathogen, associated with elevated C-reactive protein (180 mg/l), lymphopenia (830/mm 3 ), low platelet count (14,000/mm 3 ), and low prothrombin time (66%).
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