Author: Zhang, Yongli; Zhang, Hangjie; Ma, Wenqiang; Liu, Kefang; Zhao, Min; Zhao, Yingze; Lu, Xuancheng; Zhang, Fuping; Li, Xiangdong; Gao, George F.; Liu, William J.
Title: Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1(-/-) Mice Document date: 2018_10_17
ID: km6fnf5u_14
Snippet: Compared to previous work, this study establishes systematic methods to detect ZIKV-specific CD8 + T-cell responses in the brain and testes, which are immunoprivileged sites. It is important to assess the functionality of virus-specific T cells in the immunoprivileged organs of the ZIKVinfected mice. The usage of tetramers to detect ZIKV-specific CD8 + T-cell responses in immunoprivileged organs would greatly enhance our understanding of ZIKV inf.....
Document: Compared to previous work, this study establishes systematic methods to detect ZIKV-specific CD8 + T-cell responses in the brain and testes, which are immunoprivileged sites. It is important to assess the functionality of virus-specific T cells in the immunoprivileged organs of the ZIKVinfected mice. The usage of tetramers to detect ZIKV-specific CD8 + T-cell responses in immunoprivileged organs would greatly enhance our understanding of ZIKV infections and their host immune responses. Using E 294-302 tetramer, virus-specific T cells in brain and testis can be isolated by flow cytometry, to investigate the cellular mechanisms of the protection and immunopathogenesis during a ZIKV infection. Meanwhile, it is helpful for researchers to investigate further the functions of the CD8 + T cells to control the ZIKV, or to enhance the immunopathogenesis in these organs during ZIKV infection.
Search related documents:
Co phrase search for related documents- cellular mechanism and host immune response: 1, 2, 3, 4, 5, 6, 7
- cellular mechanism and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- flow cytometry and host immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9
- flow cytometry and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- flow cytometry and previous work: 1, 2, 3, 4
- flow cytometry isolate and immune response: 1
- host immune response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- host immune response and previous work: 1, 2
- host immune response ZIKV infection and immune response: 1, 2, 3
- host immune response ZIKV infection understanding and immune response: 1
- immune response and previous work: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- immune response and systematic method: 1
- previous work and systematic method: 1, 2
Co phrase search for related documents, hyperlinks ordered by date