Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_35
Snippet: There are four amphibian genomes available in the NCBI Genome database, including three frogs and one salamander (table 1). We found putatively functional CMAH homologs in all three frogs, X. tropicalis (Western clawed frog), X. laevis (African clawed frog), and Nanorana parkeri (high Himalaya frog). However, no CMAH homolog was detected in the salamander Ambystoma mexicanum (axolotl). These results suggest that the ancestor of amphibians had a f.....
Document: There are four amphibian genomes available in the NCBI Genome database, including three frogs and one salamander (table 1). We found putatively functional CMAH homologs in all three frogs, X. tropicalis (Western clawed frog), X. laevis (African clawed frog), and Nanorana parkeri (high Himalaya frog). However, no CMAH homolog was detected in the salamander Ambystoma mexicanum (axolotl). These results suggest that the ancestor of amphibians had a functional CMAH, and that it was lost in an ancestor of salamanders ( fig. 3) . Supplementary data set S2, Supplementary Material online, is a multiple sequence alignment including these sequences.
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