Author: de Sousa, Jorge Rodrigues; Da Costa Vasconcelos, Pedro Fernando; Quaresma, Juarez Antonio Simões
Title: Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases Document date: 2019_8_22
ID: jq9gcjsa_17
Snippet: The immune mechanisms inherent to the macrophage response in various organs and tissues are distinct to the pathogen-host interaction. Furthermore, these mechanisms are strongly influenced by both the infectious agents that induce a specific phenotype and the tissue characteristics of the organs where the cells are located. This phenomenon clearly demonstrates the diverse nature and importance of the response in the evolution of specific tissue l.....
Document: The immune mechanisms inherent to the macrophage response in various organs and tissues are distinct to the pathogen-host interaction. Furthermore, these mechanisms are strongly influenced by both the infectious agents that induce a specific phenotype and the tissue characteristics of the organs where the cells are located. This phenomenon clearly demonstrates the diverse nature and importance of the response in the evolution of specific tissue lesions. Elucidation of the involvement of each phenotypic macrophage subpopulations in infections in various organs and tissues would undoubtedly enhance our understanding of the complex mechanisms of interactions between pathogens and the immune system and their consequence in the genesis of tissue lesions in infectious diseases.
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