Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_9
Snippet: In cats, blood types A, B, and AB are determined by the presence or absence of Neu5Gc on certain erythrocyte glycolipids, and the absence of Neu5Gc in type B cats might be due to mutations in the 5 0 -UTR or the protein-coding regions of CMAH (Bighignoli et al. 2007; Omi et al. 2016 ). Depending on their geographical origin, dog breeds express Neu5Gc (Northern China, Korea, and Southern Japan) or not (Europe, Hokkaido dog from North of Japan) (Ya.....
Document: In cats, blood types A, B, and AB are determined by the presence or absence of Neu5Gc on certain erythrocyte glycolipids, and the absence of Neu5Gc in type B cats might be due to mutations in the 5 0 -UTR or the protein-coding regions of CMAH (Bighignoli et al. 2007; Omi et al. 2016 ). Depending on their geographical origin, dog breeds express Neu5Gc (Northern China, Korea, and Southern Japan) or not (Europe, Hokkaido dog from North of Japan) (Yasue et al. 1978; Hashimoto et al. 1984) . The molecular basis of why certain dog breeds lack Neu5Gc is yet to be elucidated.
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