Author: Laine, Outi; Joutsi-Korhonen, Lotta; Lassila, Riitta; Huhtala, Heini; Vaheri, Antti; Mäkelä, Satu; Mustonen, Jukka
Title: Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection Document date: 2016_12_30
ID: jhcc6eex_29
Snippet: In conclusion, serum TPO is upregulated and the production of platelets is enhanced during acute Puumala hantavirus disease. Serum TPO does not predict disease severity in terms of AKI. Biomarkers of thrombin generation and especially fibrinolysis are high in the absence of clinical thrombosis or major bleedings, and they associate with adverse kidney outcome. As thrombopoiesis is active and the proportion of young platelets is high, measuring th.....
Document: In conclusion, serum TPO is upregulated and the production of platelets is enhanced during acute Puumala hantavirus disease. Serum TPO does not predict disease severity in terms of AKI. Biomarkers of thrombin generation and especially fibrinolysis are high in the absence of clinical thrombosis or major bleedings, and they associate with adverse kidney outcome. As thrombopoiesis is active and the proportion of young platelets is high, measuring the activity of platelet-derived MPs with flow cytometry might clarify the role of MPs in the pathogenesis of HFRS.
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