Selected article for: "bacterial clearance and wild type"
Author: Stjärne Aspelund, Anna; Hammarström, Helena; Inghammar, Malin; Larsson, Hillevi; Hansson, Lennart; Christensson, Bertil; Påhlman, Lisa I.
Title: Heparin-binding protein, lysozyme, and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients
  • Document date: 2017_9_15
    • ID: j5w4xrr6_19
    Snippet: In this prospective study on lung transplant recipients comparing different biomarkers for prediction of infection, we found that HBP, Similar to HBP and lysozyme, all cytokines increased with the likelihood of infection, mirroring increased inflammation. IL-10 has anti-inflammatory properties but showed the same pattern as the pro-inflammatory cytokines in this study. IL-10 is believed to play an important role in balancing the inflammatory resp.....
    Document: In this prospective study on lung transplant recipients comparing different biomarkers for prediction of infection, we found that HBP, Similar to HBP and lysozyme, all cytokines increased with the likelihood of infection, mirroring increased inflammation. IL-10 has anti-inflammatory properties but showed the same pattern as the pro-inflammatory cytokines in this study. IL-10 is believed to play an important role in balancing the inflammatory response in order to limit host tissue damage. 19 For example, compared to wild-type mice, IL-10-deficient mice demonstrate more efficient bacterial clearance but higher mortality and increased neutrophil recruitment to the lung in response to Streptococcus pneumoniae infection, 20 which underscores the regulatory role of IL-10 during infection. It could therefore be speculated that IL-10 increases simultaneously with pro-inflammatory cytokines in order to avoid excessive inflammation that would be harmful to the host.

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