Author: Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.
Title: Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination Document date: 2016_3_11
ID: k3vjqumq_32
Snippet: No permanent genetic alterations of NMI expression such as mutation or deletion have been observed in cancer and many studies have identified "plastic" regulation of the NMI gene. In particular, loss of NMI in late stage breast cancer suggests that NMI is transiently down-regulated. Rostas et al. found that NMI is subject to post-transcriptional regulation by the micro-RNA 29 family in breast cancer cell lines, as well as in clinical samples. 81 .....
Document: No permanent genetic alterations of NMI expression such as mutation or deletion have been observed in cancer and many studies have identified "plastic" regulation of the NMI gene. In particular, loss of NMI in late stage breast cancer suggests that NMI is transiently down-regulated. Rostas et al. found that NMI is subject to post-transcriptional regulation by the micro-RNA 29 family in breast cancer cell lines, as well as in clinical samples. 81 Interestingly, miR-29 targeting of the NMI transcript led to a decrease in epithelial morphology and markers, as well as an enhancement of invasive properties and these data further support the previously published observations by Devine and coworkers. 81 Moreover, it suggests that NMI regulation by miR-29 is a key event in the progression of breast cancer. Additionally, miR-29 down-regulation of NMI created a feed-forward regulatory loop promoting unrestricted Wnt signaling.
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