Selected article for: "cell death and host cell"
Author: Berger, Angela K.; Danthi, Pranav
Title: Reovirus Activates a Caspase-Independent Cell Death Pathway
  • Document date: 2013_5_14
    • ID: jleccqqx_17
    Snippet: Reovirus-induced apoptotic cell death has been extensively investigated (see Fig. S4 in the supplemental material). On examination of strain-specific differences in the cell death pathways activated by reovirus, we made a surprising observation that reovirus was capable of inducing cell death even in the absence of NF-B signaling and active caspases. We found that T3D-induced cell death requires the function of RIP1 kinase, results in a drop in c.....
    Document: Reovirus-induced apoptotic cell death has been extensively investigated (see Fig. S4 in the supplemental material). On examination of strain-specific differences in the cell death pathways activated by reovirus, we made a surprising observation that reovirus was capable of inducing cell death even in the absence of NF-B signaling and active caspases. We found that T3D-induced cell death requires the function of RIP1 kinase, results in a drop in cellular ATP levels, and renders the host cell plasma membrane leaky.

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