Active Targeted Drug Delivery for Microbes Using Nano-Carriers

Lin, Yung-Sheng; Lee, Ming-Yuan; Yang, Chih-Hui; Huang, Keng-Shiang

Dendrimers were synthesized by Buhleier et al. and Tomalia et al. during 1970 Tomalia et al. during -1990 . Dendrimers are synthetic, highly branched, spherical polymers [97, 98] . Compared to traditional linear polymers, dendrimers are much superior as a drug carrier [99] . Also, they have different kinds of dendrimers; polyamidoamine dendrimer is the first one to be created [80] . There are many outstanding properties of dendrimers such as monodispersity, nano-sizes and shapes, biocompatibility, low toxicity, good pharmacokinetics and can easily provide the active targeted drug delivery [96] . Dendrimers binding ligands result in reducing cytotoxicity, hemolytic bioactives and increasing biocompatibility than the free drug [96] . The details of references related to binding ligands to treat diseases caused by microbes are summarized in (Table 3) .