Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_2
Snippet: Tetherin (BST-2, CD317) is a mammalian restriction factor, an antiviral protein that inhibits the release of diverse enveloped viral particles from the cells in which they are produced (17) (18) (19) . These viruses include retroviruses, coronaviruses, filoviruses, and paramyxoviruses, some of which are transmissible by bats (20, 21) . Tetherin is a membrane-associated glycoprotein and its activity is determined by its structure, rather than its .....
Document: Tetherin (BST-2, CD317) is a mammalian restriction factor, an antiviral protein that inhibits the release of diverse enveloped viral particles from the cells in which they are produced (17) (18) (19) . These viruses include retroviruses, coronaviruses, filoviruses, and paramyxoviruses, some of which are transmissible by bats (20, 21) . Tetherin is a membrane-associated glycoprotein and its activity is determined by its structure, rather than its primary amino acid sequence (22, 23) . Tetherin has been shown to possess a secondary role in immune signaling events by triggering the NF-κB signaling pathway, leading to stimulation of the antiviral interferon response (24) (25) (26) (27) .
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