Author: Bein, Thomas; Grasso, Salvatore; Moerer, Onnen; Quintel, Michael; Guerin, Claude; Deja, Maria; Brondani, Anita; Mehta, Sangeeta
Title: The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia Document date: 2016_4_4
ID: krpg9u1u_13
Snippet: The effect of respiratory rate (RR) on the occurrence of VALI or outcome in ARDS has not been independently studied. Lung injury may be related to the frequency of repetitive collapse and expansion [17] , i.e., how often the lungs are exposed to a given stress and strain. The degree of tissue damage probably depends on the pressure amplitude and to a lesser extent on the frequency with which it is applied [18, 19] . However, a higher respiratory .....
Document: The effect of respiratory rate (RR) on the occurrence of VALI or outcome in ARDS has not been independently studied. Lung injury may be related to the frequency of repetitive collapse and expansion [17] , i.e., how often the lungs are exposed to a given stress and strain. The degree of tissue damage probably depends on the pressure amplitude and to a lesser extent on the frequency with which it is applied [18, 19] . However, a higher respiratory rate might prevent expiratory derecruitment by reducing expiratory time and causing intrinsic PEEP [20] . In a large animal model of VALI, higher RR was associated with less pulmonary inflammation, but increased lung edema [21] . Accordingly, a high RR might influence the amount of extrinsic PEEP, and the current status of the lungs in terms of (de)recruitment, regional compliance, and resistance.
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