Selected article for: "chimeric protein and CT domain"
Author: Lv, Lishan; Li, Xiaoming; Liu, Genmei; Li, Ran; Liu, Qiliang; Shen, Huifang; Wang, Wei; Xue, Chunyi; Cao, Yongchang
Title: Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus
  • Document date: 2014_6_16
    • ID: k785hl1r_3
    Snippet: In this study, we generated a fusion protein in which the IBV S1 protein was fused to the cytoplasmic tail (CT) and the transmembrane (TM) domain of avian influenza H5N1 virus NA protein. The results showed that the fusion protein and avian influenza virus M1 protein were efficiently assembled to form chimeric VLPs. These chimeric VLPs were then prepared quantitatively and used as immunogens in BALB/c mice and SPF chickens. When compared with the.....
    Document: In this study, we generated a fusion protein in which the IBV S1 protein was fused to the cytoplasmic tail (CT) and the transmembrane (TM) domain of avian influenza H5N1 virus NA protein. The results showed that the fusion protein and avian influenza virus M1 protein were efficiently assembled to form chimeric VLPs. These chimeric VLPs were then prepared quantitatively and used as immunogens in BALB/c mice and SPF chickens. When compared with the IBV inactivated vaccine, the chimeric VLPs induced higher immune responses. Taken together, the chimeric VLPs showed the potential for use as a candidate vaccine against IBV.

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