Author: Zhang, Chunsun; Xing, Da
Title: Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends Document date: 2007_6_18
ID: j0bazhy2_59
Snippet: Although the partially integrated PCR chips have been successfully developed, the PCR-based 'complete' lab-ona-chip still requires further development. The bottlenecks blocking the realization of a truly and highly integrated PCR chip include on-chip pre-PCR sample preparation and on-chip PCR product detection. Since the source of raw template samples is varied and the sample preparation methods are diverse, the miniaturization of conventional sa.....
Document: Although the partially integrated PCR chips have been successfully developed, the PCR-based 'complete' lab-ona-chip still requires further development. The bottlenecks blocking the realization of a truly and highly integrated PCR chip include on-chip pre-PCR sample preparation and on-chip PCR product detection. Since the source of raw template samples is varied and the sample preparation methods are diverse, the miniaturization of conventional sample preparation and functionalities on a chip remains (11, 17, 22, 32, 60) and others (31, 32, 50, 53, 69, 77) .
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