Author: Ross D. Overacker; Somdev Banerjee; George F. Neuhaus; Selena Milicevic Sephton; Alexander Herrmann; James A. Strother; Ruth Brack-Werner; Paul R. Blakemore; Sandra Loesgen
Title: Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline Document date: 2019_1_23
ID: m2zw8eq4_55
Snippet: We observed precipitation of some azaBINOL compounds at concentrations higher than 200 571 µM in cell media with 1% DMSO. To assess if the antiviral activity from the active azaBINOL 572 compound B#24 could be due to non-specific aggregation effects, an 1 H-NMR assay was 573 implemented to characterize compound behavior in aqueous conditions as described 574.....
Document: We observed precipitation of some azaBINOL compounds at concentrations higher than 200 571 µM in cell media with 1% DMSO. To assess if the antiviral activity from the active azaBINOL 572 compound B#24 could be due to non-specific aggregation effects, an 1 H-NMR assay was 573 implemented to characterize compound behavior in aqueous conditions as described 574
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