Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

Laine, Outi; Joutsi-Korhonen, Lotta; Lassila, Riitta; Huhtala, Heini; Vaheri, Antti; Mäkelä, Satu; Mustonen, Jukka

D-dimer was 7-fold higher acutely compared with the value measured at control visit in this group of PUUV-infected patients. F1 + 2 was clearly elevated ( Table 2 ) and it associated with serum TPO level (r = 0.47, P = 0.03). Both D-dimer and F1 + 2 associated with minimum platelet count (r = À0.48, P = 0.01 and r = À0.46, P = 0.02, respectively), plasma creatinine level at the time of the measurement (r = 0.57, P = 0.002 and r = 0.50, P = 0.008, respectively) and maximum plasma creatinine (r = 0.54, P = 0.004 and r = 0.42, P = 0.03, respectively). MPs' activity in the acute phase of the disease did not differ from the activity observed at the recovery when patients were divided into 2 groups (below or above median value) based on the platelet count at the time of the MPs' activity measurement or the lowest platelet count.