Selected article for: "Frameshift efficiency and stem loop"
Author: Mouzakis, Kathryn D.; Lang, Andrew L.; Vander Meulen, Kirk A.; Easterday, Preston D.; Butcher, Samuel E.
Title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome
  • Document date: 2012_12_15
    • ID: ix8du1er_39
    Snippet: When the HIV-1 frameshift site is modeled onto the eukaryotic ribosome, base pairs critical for frameshifting are positioned at the entrance to the mRNA entry channel ( Figure 5B and D), in agreement with chemical probing and toeprinting results with a prokaryotic ribosome stalled on the HIV-1 frameshift site (23) . Interestingly, the decoding center and the mRNA channel are highly conserved between prokaryotes and eukaryotes (65) and a bacterial.....
    Document: When the HIV-1 frameshift site is modeled onto the eukaryotic ribosome, base pairs critical for frameshifting are positioned at the entrance to the mRNA entry channel ( Figure 5B and D), in agreement with chemical probing and toeprinting results with a prokaryotic ribosome stalled on the HIV-1 frameshift site (23) . Interestingly, the decoding center and the mRNA channel are highly conserved between prokaryotes and eukaryotes (65) and a bacterial translation system produces similar levels and changes in frameshift efficiency in response to changes in the HIV-1 stem-loop sequence (11) .

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