Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate

Basso, Maria Alexandra; Marques, Cátia; Santos, Marcos; Duarte, Ana; Pissarra, Hugo; Carreira, L Miguel; Gomes, Lídia; Valério-Bolas, Ana; Tavares, Luís; Santos-Gomes, Gabriela; Pereira da Fonseca, Isabel

The cat was medicated with antibiotic (amoxicillin/ clavulanic acid, 12.5 mg/kg PO q12h for 10 days) and a non-steroidal anti-inflammatory (tolfenamic acid 4 mg/ kg PO q 24h for 4 days), and was assessed 48 h after surgery in order to evaluate the regions operated on; stitches were removed on days 6 and 12. As an integral part of the healing process, the cat was maintained for 2 weeks with Robert-Jones bandages. The complete healing of hindlimb lesions was achieved 1 month after surgery ( Figure 6 ). Histological examination of the removed tissues showed a granulomatous-like inflammatory response with some foci of lymphocytes, activated plasmacytes and occasional intracellular amastigote forms of Leishmania species in macrophages.