Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_48
Snippet: Research is progressing on the construction of minimal synthetic or semi-synthetic cells by a bottom-up approach by encapsulating different macromolecules into a lipid vesicle. In situ generation of enzymes and proteins is a prerequisite for constructing functional cells that can replicate their genetic material or respond to chemical messengers by means of surface-mediated receptors [25] . Liposomes have been studied as the most likely precursor.....
Document: Research is progressing on the construction of minimal synthetic or semi-synthetic cells by a bottom-up approach by encapsulating different macromolecules into a lipid vesicle. In situ generation of enzymes and proteins is a prerequisite for constructing functional cells that can replicate their genetic material or respond to chemical messengers by means of surface-mediated receptors [25] . Liposomes have been studied as the most likely precursors of biological cells, and complex biochemical reactions have been described inside liposomes, up to the expression of proteins. The cell membrane between the inner and outer environment of the compartment should have specific properties such as semi-permeability to enable cell-to-cell communication and molecular transport [26] . Such membranes can be built from natural constituents or from synthetic polymers. Synthetic cells could include essential components for a personalized therapy and would be a cheaper and more effective tool for treatment.
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