Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_68
Snippet: Discoveries made through application of human genome sequencing have already an impact on practice of oncology and have influenced the design of clinical trials for new cancer therapies. In the future, research into cancer will expand to generate full genome sequences of various cancers, yielding complete catalogues of somatic mutations in each one. These studies will reveal essentially the full repertoire of mutated cancer genes, enabling us to .....
Document: Discoveries made through application of human genome sequencing have already an impact on practice of oncology and have influenced the design of clinical trials for new cancer therapies. In the future, research into cancer will expand to generate full genome sequences of various cancers, yielding complete catalogues of somatic mutations in each one. These studies will reveal essentially the full repertoire of mutated cancer genes, enabling us to determine how many and what combinations of mutated cancer genes are necessary to generate an individual cancer. Sequencing is evolving from a research tool to applications for cancer diagnostics. Analyses of the cancer genome as well as the transcriptome and their applications into clinical trials in order to exploit the full clinical potential of information within the cancer genome are generating new predictors of drug responsiveness and prognosis, which will enable personalized management of cancer [36] .
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