Animal models for dengue vaccine development and testing

Na, Woonsung; Yeom, Minjoo; Choi, Il-Kyu; Yook, Heejun; Song, Daesub

The establishment of dengue-susceptible model mice expressing critical DENV receptors and their application in stuhttp://www.ecevr.org/ https://doi.org/10.7774/cevr.2017.6.2.104 dies of the pathological and molecular mechanisms of DENV should provide an opportunity to accumulate new scientific knowledge. Accelerating this basic research will broaden the possibilities for vaccine development by making it possible to overcome various obstacles, namely the absence of suitable animal models, that have hindered progress. The development of a DENV infection disease model through transformation will accelerate basic research and present creative directions for cooperation in basic research and applied science. Research to establish animal models is very important for improving disease diagnosis as well as the development of vaccines and new drugs. Animal models play a particularly important role in proving the efficacy and safety of new vaccines at the preclinical and clinical stages. Currently, many countries, including the United States, are making efforts to establish vaccine development systems using animal models. Dengue receptor-expressing mice will not only help to develop useful biomarkers but also optimize preclinical results (safety and efficacy), leading to clinical trials, which should increase the success rate of and shorten the time required for new vaccine development. However, since these studies are short-term, profitable projects, it is urgent to provide national support for the development of intermediary research.