Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_57
Snippet: A biocompatible as well as biodegradable nanoparticle has been designed by computer modeling, which self-assembles from single polypeptide chains to produce a structure with isohedral symmetry and a diameter of ϳ 16 nm [31] . These peptide nanoparticles are multifunctional with high binding affinity and specificity. They can be customized to a high functional density. This platform was used to design and produce a prototypic ma-laria vaccine tha.....
Document: A biocompatible as well as biodegradable nanoparticle has been designed by computer modeling, which self-assembles from single polypeptide chains to produce a structure with isohedral symmetry and a diameter of ϳ 16 nm [31] . These peptide nanoparticles are multifunctional with high binding affinity and specificity. They can be customized to a high functional density. This platform was used to design and produce a prototypic ma-laria vaccine that can repetitively display a tandem repeat of the B cell immunodominant repeat epitope of the circumsporozoite protein of rodent malaria parasite Plasmodium berghei [32] . Administered without an adjuvant, this vaccine conferred a long-lasting antibody response against B cell epitope and protected mice against malarial parasite for up to 6 months.
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