Selected article for: "TCR transgenic and transgenic mouse"

Author: Brabb, Thea; von Dassow, Peter; Ordonez, Nadia; Schnabel, Bryan; Duke, Blythe; Goverman, Joan
Title: In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity
  • Document date: 2000_9_18
  • ID: kcygxo7h_14
    Snippet: A second MBP TCR transgenic model (MBP TCR2) also demonstrated normal numbers of T cells within the CNS compared with age-matched nontransgenic mice ( Fig. 1 ). Of eight MBP TCR2 transgenic mice analyzed, only one mouse exhibited an abnormally high number of T cells (1.5 Ï« 10 6 T cells/g, 100-fold higher than the average T cell count). Data from this mouse were not included in Fig. 1 because of the possibility that this animal was developing spo.....
    Document: A second MBP TCR transgenic model (MBP TCR2) also demonstrated normal numbers of T cells within the CNS compared with age-matched nontransgenic mice ( Fig. 1 ). Of eight MBP TCR2 transgenic mice analyzed, only one mouse exhibited an abnormally high number of T cells (1.5 Ï« 10 6 T cells/g, 100-fold higher than the average T cell count). Data from this mouse were not included in Fig. 1 because of the possibility that this animal was developing spontaneous disease.

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