Selected article for: "effector mechanism and immune system"
Author: Bautista-Hernández, Luis Antonio; Gómez-Olivares, José Luis; Buentello-Volante, Beatriz; Bautista-de Lucio, Victor Manuel
Title: Fibroblasts: The Unknown Sentinels Eliciting Immune Responses Against Microorganisms
  • Document date: 2017_8_19
    • ID: j4lfwdbh_8
    Snippet: We know that the innate immune system is the fi rst line of response to pathogens, and this response generally includes three events: microbial recognition, activation of signaling pathways, and activation of an effector mechanism. The recognition of pathogens is mediated by TLRs, which are membrane proteins that recognize specifi c pathogens associated molecular patterns (PAMPs). TLRs have an amino terminal leucine rich repeat (LRR) domain and a.....
    Document: We know that the innate immune system is the fi rst line of response to pathogens, and this response generally includes three events: microbial recognition, activation of signaling pathways, and activation of an effector mechanism. The recognition of pathogens is mediated by TLRs, which are membrane proteins that recognize specifi c pathogens associated molecular patterns (PAMPs). TLRs have an amino terminal leucine rich repeat (LRR) domain and an intracellular carboxyl terminal domain that contains a conserved region known as the toll/intercellular receptor (TIR). The TLR family comprises 10 TLRs (TLR1 to TLR10 have been reported thus far) [9, 10] .

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