Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

Laine, Outi; Joutsi-Korhonen, Lotta; Lassila, Riitta; Huhtala, Heini; Vaheri, Antti; Mäkelä, Satu; Mustonen, Jukka

The inverse association between serum TPO level and platelet functions measured by both PFA-100 and Multiplate was clear, as was the positive association between TPO and IPF%. TPO has been reported to enhance platelet activation during burn injury [21] and increase platelet adhesion under flow. [22] Moreover, high TPO has a priming effect on platelet aggregation in response to different agonists. [23] In this study, the effect of low platelet count on platelet aggregation was not compensated by the simultaneously occurring elevated TPO level and high proportion of young platelets. As major bleeding problems were avoided and no thromboembolic complications were noted, hemostasis appears clinically balanced in spite of laboratory findings reflecting impairment of primary hemostasis.