Author: Zhang, Yongli; Zhang, Hangjie; Ma, Wenqiang; Liu, Kefang; Zhao, Min; Zhao, Yingze; Lu, Xuancheng; Zhang, Fuping; Li, Xiangdong; Gao, George F.; Liu, William J.
Title: Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1(-/-) Mice Document date: 2018_10_17
ID: km6fnf5u_18
Snippet: In conclusion, we present the methods of detecting antigen-specific T-cell responses in the immunoprivileged organs of the Ifnar1 -/mouse model for a ZIKV infection. This platform can be widely applied to investigate the immune mechanisms of emerging and re-emerging viruses which can bypass the barriers between the blood and the immunoprivileged organs. Moreover, this study may pave the way for the future development of candidate vaccines and imm.....
Document: In conclusion, we present the methods of detecting antigen-specific T-cell responses in the immunoprivileged organs of the Ifnar1 -/mouse model for a ZIKV infection. This platform can be widely applied to investigate the immune mechanisms of emerging and re-emerging viruses which can bypass the barriers between the blood and the immunoprivileged organs. Moreover, this study may pave the way for the future development of candidate vaccines and immunotherapies.
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