Author: Gao, Shuibo; Li, Enyao; Gao, Haixia
Title: Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway Document date: 2019_8_21
ID: jwrv3e6j_21
Snippet: In order to probe the influence of MEG3 up-regulation on morphine-caused HT22 cell autophagy, si-MEG3 was transfected into HT22 cells. Figure 4(A) showed that the MEG3 expression in HT22 cells was dramatically declined by si-MEG3 transfection (p Ë‚ 0.01). By contract with morphine þ si-NC group, the Beclin-1 protein level and LC3-II/LC3-I expression rate in HT22 cells were both lowered in morphine þ si-MEG3 group (Figure 4(B) , p Ë‚ 0.05 or p Ë.....
Document: In order to probe the influence of MEG3 up-regulation on morphine-caused HT22 cell autophagy, si-MEG3 was transfected into HT22 cells. Figure 4(A) showed that the MEG3 expression in HT22 cells was dramatically declined by si-MEG3 transfection (p ˂ 0.01). By contract with morphine þ si-NC group, the Beclin-1 protein level and LC3-II/LC3-I expression rate in HT22 cells were both lowered in morphine þ si-MEG3 group (Figure 4(B) , p ˂ 0.05 or p ˂ 0.01). These outcomes illustrated that upregulation of MEG3 attended to the influence of morphine on HT22 cell autophagy.
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