Author: Luo, Cheng-Xin; Wen, Zhong-Hui; Zhen, Yu; Wang, Zhu-Jun; Mu, Jing-Xi; Zhu, Min; Ouyang, Qin; Zhang, Hu
Title: Chinese research into severe ulcerative colitis has increased in quantity and complexity Document date: 2018_3_16
ID: jmjtr1pb_18
Snippet: Intravenous corticosteroids treatment remains the first-line therapy; however, the assessment of response to therapy remains a great challenge. Predictors and predictive indices for the failure of steroid therapy and the subsequent need for colectomy have been widely studied. Nine of the 96 original research articles focused on corticosteroid treatment, in which 800 patients with SUC received corticosteroids as the principal therapy. Three of the.....
Document: Intravenous corticosteroids treatment remains the first-line therapy; however, the assessment of response to therapy remains a great challenge. Predictors and predictive indices for the failure of steroid therapy and the subsequent need for colectomy have been widely studied. Nine of the 96 original research articles focused on corticosteroid treatment, in which 800 patients with SUC received corticosteroids as the principal therapy. Three of these 9 articles reported both outcome and predictors of therapy failure, while 6 only reported outcomes. The effective rate of steroid treatment ranged from 58.3% to 90%, with a pooled effective rate of 67.3%. Previous severe attack and onset with stool frequency ≥ 10/d are associated with increased rates of steroids failure. Further predictors of steroid treatment failure include: A stool frequency ≥ 6/d, obvious bloody stool, severe hypoalbuminemia, and an elevated platelet count after 3 d of intravenous steroids.
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