Author: Na, Woonsung; Yeom, Minjoo; Choi, Il-Kyu; Yook, Heejun; Song, Daesub
Title: Animal models for dengue vaccine development and testing Document date: 2017_7_26
ID: jlmuo37x_6
Snippet: When DENV is inoculated into the brain of suckling mice, encephalitis and paralysis are observed; therefore, this is used as a model for evaluation of the efficacy of antivirals and vaccines against the neurovirulence of DENV [13] . Although immunocompetent mice do not show the symptoms of DENV infection, high-dose inoculation can cause clinical signs, and evaluation of this immune response can improve our understanding of disease severity and th.....
Document: When DENV is inoculated into the brain of suckling mice, encephalitis and paralysis are observed; therefore, this is used as a model for evaluation of the efficacy of antivirals and vaccines against the neurovirulence of DENV [13] . Although immunocompetent mice do not show the symptoms of DENV infection, high-dose inoculation can cause clinical signs, and evaluation of this immune response can improve our understanding of disease severity and the mechanism of disease development [14] . In addition, inoculation of mast cell knockout C57BL/6 mice with two different DENVs was shown to induce vascular leakage [15] . A model in which human cells were transplanted into NOD/SCID mice lacking T, B, and natural killer cells; complement-5 (C-5); and macrophages was developed, which presented a human-like disease mechanism after infection with DENV [16] . Additionally, a NOD/ SCID/IL-2Rcc -/mouse model transplanted with human cells was developed that shows human-like disease patterns [17, 18] .
Search related documents:
Co phrase search for related documents- cell knockout and immune response: 1, 2, 3, 4
- clinical sign and disease severity: 1, 2, 3, 4, 5, 6
- clinical sign and high dose: 1, 2, 3
- clinical sign and immune response: 1, 2, 3
- DENV infection and different denv: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- DENV infection and different denv mouse: 1, 2
- DENV infection and disease severity: 1, 2, 3, 4, 5
- DENV infection and high dose: 1
- DENV infection and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9
- DENV infection and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- different denv and disease severity: 1, 2
- different denv and human cell: 1, 2, 3, 4, 5
- different denv and immune response: 1, 2, 3, 4, 5, 6
- different denv mouse and immune response: 1
- disease development mechanism and high dose: 1
- disease development mechanism and human cell: 1, 2
- disease mechanism and high dose: 1, 2, 3
- disease mechanism and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- disease mechanism and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date