Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_46
Snippet: An inactivation of CMAH is known to have occurred in a human ancestor, $2.5-3 Ma (Hayakawa et al. 2001; Chou et al. 2002 ). An Alu insertion resulted in a deletion of a genomic region encompassing coding exon 3, a 92-bp exon that codes for part of the Rieske catalytic domain. Our genomic analyses also found all the protein coding exons of the human gene except exon 3 (relative to chimp coding sequence)......
Document: An inactivation of CMAH is known to have occurred in a human ancestor, $2.5-3 Ma (Hayakawa et al. 2001; Chou et al. 2002 ). An Alu insertion resulted in a deletion of a genomic region encompassing coding exon 3, a 92-bp exon that codes for part of the Rieske catalytic domain. Our genomic analyses also found all the protein coding exons of the human gene except exon 3 (relative to chimp coding sequence).
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