Author: Capelozzi, Vera Luiza; Parra, Edwin Roger; Ximenes, Manoel; Bammann, Ricardo Helbert; Barbas, Carmen Silvia Valente; Duarte, Marid Irmd Seixas
Title: Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type A/H1N1 and acute respiratory failure Document date: 2010_12_23
ID: iv18eiap_10
Snippet: The ultrastructural features were represented by bronchial and alveolar epithelium necrosis, a destroyed alveolar epithelium/basement membrane unity and the presence of viral-like particles (Table 3) . Patients 3 and 5 presented more prominent changes at submicroscopic level. Cytoplasmic swelling, necrosis, and degenerative changes of the endoplasmic reticulum and other organelles were present in bronchial and AECs (Figure 2A-C) . A large number .....
Document: The ultrastructural features were represented by bronchial and alveolar epithelium necrosis, a destroyed alveolar epithelium/basement membrane unity and the presence of viral-like particles (Table 3) . Patients 3 and 5 presented more prominent changes at submicroscopic level. Cytoplasmic swelling, necrosis, and degenerative changes of the endoplasmic reticulum and other organelles were present in bronchial and AECs (Figure 2A-C) . A large number of bronchiolar and AECs were detached from the basement membrane and were showing apoptosis (Figure 2A, B) . Lymphocytes also exhibited apoptosis. Sloughing of apoptotic bronchiolar cells and AECs causing denudation of the epithelial basement membrane was followed by deposition of hyaline membranes ( Figure 2D ).
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