Author: Mordecai, Gideon J; Wilfert, Lena; Martin, Stephen J; Jones, Ian M; Schroeder, Declan C
Title: Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies Document date: 2015_11_17
ID: k2n6ropo_4
Snippet: There are numerous biological implications of quasispecies occupying large amounts of sequence space that challenge the treatment and control of both established and emerging infectious diseases (Gomez et al., 1999) . For example, quasispecies theory has been used to describe how viruses such as Hepatitis C virus and HIV are able to escape host immune responses (Pavio and Lai, 2003; Woo and Reifman, 2012) . In addition, effective vaccines are yet.....
Document: There are numerous biological implications of quasispecies occupying large amounts of sequence space that challenge the treatment and control of both established and emerging infectious diseases (Gomez et al., 1999) . For example, quasispecies theory has been used to describe how viruses such as Hepatitis C virus and HIV are able to escape host immune responses (Pavio and Lai, 2003; Woo and Reifman, 2012) . In addition, effective vaccines are yet to be developed for both these viruses because of the rapid emergence of resistant mutants under vaccine selection pressure (Gaschen et al., 2002; Law et al, 2013) . For similar reasons, the highly divergent nature of RNA viruses has been implicated in the emergence of antiviral drug-resistant infections in AIDS (Metzner et al., 2009 ), hepatitis C (Halfon and Locarnini, 2011) , hepatitis B (Nishijima et al., 2012) and influenza (Boivin et al., 2002) .
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