Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_54
Snippet: The chimpanzee CMAH coding sequence (CDS) consists of 15 exons. The Rieske iron-sulphur domain, which contains the active site of the CMAH enzyme, is sequenced by exons 2-4 (position 43-345 bp in the chimp CDS). The structure of the gene is generally well conserved across deuterostomes, with the following exceptions. First, echinoderms and hemichordates exhibit an extra intron that interrupts exon 11, at a position that is equivalent to position .....
Document: The chimpanzee CMAH coding sequence (CDS) consists of 15 exons. The Rieske iron-sulphur domain, which contains the active site of the CMAH enzyme, is sequenced by exons 2-4 (position 43-345 bp in the chimp CDS). The structure of the gene is generally well conserved across deuterostomes, with the following exceptions. First, echinoderms and hemichordates exhibit an extra intron that interrupts exon 11, at a position that is equivalent to position 1329 of the chimpanzee CDS (see supplementary data set S3, Supplementary Material online). Second, all studied fish, except Latimeria chalumnae (coelacanth) and Lepisosteus oculatus (spotted gar), exhibit an extra intron that interrupts exon 6 (after nucleotide 702 of the chimpanzee coding sequence). This suggests an intron insertion in teleost fishes. Third, the CMAH gene of A. carolinensis lacks the intron between exons 6 and 7 (after nucleotide 768 of the chimpanzee coding sequence).
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