Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study

van de Hei, Susanne; McKinstry, Steven; Bardsley, George; Weatherall, Mark; Beasley, Richard; Fingleton, James

Complete resolution of symptoms, denoted by a modified Jackson score of zero, occurred in 330 only 12 participants within 10 days after randomisation; 10 of 19 participants who completed the 331 modified Jackson Score on day 10 in the rhinothermy group and two of 10 in the Vitamin C 332 group. The hazard ratio (95% CI) for feeling 'a lot better' rhinothermy compared to control was 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 The SDs for the modified Jackson score at Days 4 and 5, based on the pooled values from t-351 tests, were 3.8 (95% CI 3.0 to 5.2) and 4.8 (3.8 to 6.6); and for change from baseline modified 352 Jackson score 3.7 (95% CI 2.9 to 5.0) and 4.7 (3.7 to 6.5). 353 354