Selected article for: "genome sense and RNA dependent RNA polymerase"
Author: Penno, Christophe; Kumari, Romika; Baranov, Pavel V.; van Sinderen, Douwe; Atkins, John F.
Title: Stimulation of reverse transcriptase generated cDNAs with specific indels by template RNA structure: retrotransposon, dNTP balance, RT-reagent usage
  • Document date: 2017_9_29
    • ID: k4gtl2o7_54
    Snippet: Replication of the single-stranded, positive sense, RNA genome of SARS Coronavirus involves a viral-encoded RNA-dependent RNA polymerase. Polymerase expression involves -1 ribosomal frameshifting at a U-UUA-AAC se-quence (55) (56) (57) . Together with 5 bases, it is part of a GU5A3C sequence. Interestingly, a potential 10 bp-stem 4 nt-loop structure forms 2 nt 5 to the GU5A3C sequence and causes reduced frameshift-derived product (58) . During re.....
    Document: Replication of the single-stranded, positive sense, RNA genome of SARS Coronavirus involves a viral-encoded RNA-dependent RNA polymerase. Polymerase expression involves -1 ribosomal frameshifting at a U-UUA-AAC se-quence (55) (56) (57) . Together with 5 bases, it is part of a GU5A3C sequence. Interestingly, a potential 10 bp-stem 4 nt-loop structure forms 2 nt 5 to the GU5A3C sequence and causes reduced frameshift-derived product (58) . During replication of the (+) strand such a stem-loop would be ahead (5 ) of the U5A3 motif. This raises the possibility of it leading to road-block-induced slippage at the U5A3 motif, and so being a counterpart of the situation shown for the HIV frameshift site. The potential for HIV functional utilization of RT and its implications are considered in the accompanying ms (59) .

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