Author: Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Carlyle Ribeiro Lima; Franklin Souza da Silva; André C. Ferreira; Mayara Mattos; Caroline S. de Freitas; Vinicius Cardoso Soares; Suelen da Silva Gomes Dias; Jairo R. Temerozo; Milene Miranda; Aline R. Matos; Fernando A. Bozza; Nicolas Carels; Carlos Roberto Alves; Marilda M. Siqueira; Patrícia T. Bozza; Thiago Moreno L. Souza
Title: Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production Document date: 2020_4_5
ID: 6zk0ioep_2
Snippet: The novel 2019 CoV is phylogenetically closer to SARS-CoV (from the 2002 outbreak) than MERS-CoV (from 2012 outbreak) 2, 3 . Both SARS-and MERS-CoV raised international public health concerns with rates of mortality of 10 and 35%, respectively 4, 5 . Soon after its discovery, the contemporary SARS-CoV-2 became a pandemic threat, with the number of confirmed infections ramping up globally 6 . To date, SARS-CoV-2 is responsible for 10 times more de.....
Document: The novel 2019 CoV is phylogenetically closer to SARS-CoV (from the 2002 outbreak) than MERS-CoV (from 2012 outbreak) 2, 3 . Both SARS-and MERS-CoV raised international public health concerns with rates of mortality of 10 and 35%, respectively 4, 5 . Soon after its discovery, the contemporary SARS-CoV-2 became a pandemic threat, with the number of confirmed infections ramping up globally 6 . To date, SARS-CoV-2 is responsible for 10 times more deaths than the total sum from SARS-and MERS-CoV, with more causalities daily that are continue to scale up 6 .
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