Active Targeted Drug Delivery for Microbes Using Nano-Carriers

Lin, Yung-Sheng; Lee, Ming-Yuan; Yang, Chih-Hui; Huang, Keng-Shiang

Although the active targeted strategy using nano-carriers has been solved many concerns from the conventional drug strategy, there is still a challenge reported by some researches [117] . Active targeted strategy was a notable and efficient approach to send drug toward the pathogenic organs, however, Kunjachan et al. reported active targeted strategy should not be overestimated because the drug retention time using the active targeted approach would be diminished easily in the animal model [46] . Besides, active targeted delivery needs highly specific target recognition and great deal of target binding affinity. In hence, length of branches carrying a ligand and the number of ligands per siRNA HIV(CXCR4 co-receptor) Blocking HIV viral entry and reducing infection [113] siRNA HIV(CXCR4 co-receptors) Reducing 60% expression levels of CXCR4 [114] FMDV peptides FMDV (Protein VP1) Showing immunogenicity and eliciting antibody response [115] FMDV peptides FMDV(B cell epitope) Enhancing significantly the virus neutralizing antibody titers [116] *HIV: Human immunodeficiency virus; FMDV: Foot-and-mouth disease virus nano-carriers should be considered [112] . Besides, the most of papers about active targeted drug delivery for microbes we collected are in vitro, scientists could further use in vivo model to determine the efficacy of active targeted strategy in the future.